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Rejuran Healer
Korea's most popular polynucleotide product. Standard option for skin renewal. Suitable for all skin types, general anti-aging.
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Biological Skin Renewal · Nişantaşı
Istanbul Polynucleotide
Skin Renewal, Anti-Aging
Google Score
500+ Reviews
Established
6+ Years Experience
Certified Device
Alma Soprano Ice
Specialist Doctor
Op. Dr. Atakan Baş
Language Support
International Service
New generation biological skin renewal with Rejuran (Korea) and Plinest (Italy). Applied by Op. Dr. Atakan Baş, especially for under-eye and fine lines.
Performed By
Plastic Surgeon + Specialist Dermatologist
Duration
30-45 Minutes
Sessions
3-4 Sessions
Brands
Rejuran + Plinest
What is Polynucleotide?
New generation biological skin renewal
Polynucleotide is purified nucleic acid fragments obtained from salmon DNA. When injected into the skin, it triggers cell renewal, initiates DNA-level healing, and activates the skin's own healing mechanisms.
Unlike fillers and mesotherapy, polynucleotide doesn't add volume — instead, it renews the skin tissue from within. It activates fibroblast cells, gradually increases collagen and elastin synthesis, and improves micro-circulation.
It has been the most popular application of the last 2 years, especially for dark under-eye circles, fine wrinkles, skin laxity, acne scars, and general skin quality. Rejuran (Korea) is the global standard, Plinest (Italy) is the European alternative.
Brands and Types Used
Polynucleotide applications offered
Each brand and type comes with special formulations for different skin needs.
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Rejuran I (Eye)
Low viscosity version specially formulated for the under-eye area. Ideal for dark circles, fine lines, and bags.
03
Rejuran S (Scar)
Special formula for acne scars and atrophic scars. Effect is enhanced when combined with microneedling.
04
Rejuran HB+ (Plus)
Hyaluronic acid-enriched version. Both renews skin tissue and provides hydration.
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Plinest (Italy)
Italian Mastelli company product. PDRN-based, European-sourced polynucleotide. EU CE certified safety standards.
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Newest / Plinest Fast
New generation fast-acting formula. Visible results within 2 weeks after the first session.
Process
Treatment process
Every step from consultation to result.
1
Consultation
Skin analysis, problem area identification, suitable product selection.
2
Preparation
Skin cleaning, anesthetic cream (mandatory for under-eye), 20-minute wait.
3
Application
Micro-injections. Cannula preferred for under-eye.
4
Follow-up
Check-up and next session 2-3 weeks later. Total 3-4 sessions.
Our Surgeon
Our Surgeon
Op. Dr. Atakan Baş
Specialist in Plastic, Reconstructive and Aesthetic Surgery
Graduate of Ankara University Faculty of Medicine. Completed specialty training at University of Health Sciences Ankara City Hospital.
More Info →Frequently Asked Questions
Common questions
Polynucleotide is purified nucleic acid fragments obtained from salmon DNA. It triggers skin cell renewal at the DNA level. It is biocompatible and does not cause allergic reactions.
Filler adds volume, polynucleotide renews skin tissue from within. While filler provides instantly visible results, polynucleotide provides gradual and natural renewal. They serve different purposes.
Polynucleotide improves micro-circulation in the under-eye area, reduces dark circles, and softens fine lines. Unlike filler, it renews the area without adding volume. For this reason, it is considered the most suitable option for the under-eye.
After the first session, improvement in skin tone is felt. Notable changes begin after the 2nd session. 3-4 sessions are needed for full effect.
Applied with very fine needles. Comfort is enhanced with anesthetic cream. Cannula technique is preferred in sensitive areas like under-eye — less painful and lower bruising risk.
Rejuran is of Korean origin and more widely used globally. Plinest is Italian-produced, EU-standard alternative. The effect principle is similar, but formulation details differ. Selection is made by physician decision.
Mild swelling may occur 24-48 hours after application. Small bumps at injection points in the under-eye disappear within 1-3 days. Full healing takes 5-7 days.
Prices vary by product used and number of sessions. For current pricing, please call +90 212 561 23 22.
Pregnancy, breastfeeding, active skin infection, autoimmune diseases, and salmon allergy are contraindications. Full assessment is made during physician consultation.
Treatments are performed by Plastic Surgeon Op. Dr. Atakan Baş with experienced micro-injection techniques.
Yes. We use original Allergan Botox® approved by the FDA and Turkish Ministry of Health. The procedure is performed exclusively by Plastic Surgeon Op. Dr. Atakan Baş in sterile clinical conditions.
On average 4-6 months. With regular sessions, the effect duration may extend and less product is needed over time.
Effects begin within 3-7 days, with full results visible by day 14. You can return to daily activities immediately after the procedure.
For the first 4 hours: do not lie flat, do not massage the area. Avoid intense exercise and heat (sauna, hammam) for 24 hours. These rules ensure the product stays in the target muscle.
Most commonly: forehead lines, glabella (frown lines), crow's feet, masseter (jaw slimming), bunny lines (around nose) and gummy smile. Also effective for migraines and excessive sweating.
When applied at correct doses to correct anatomical points, side effect risk is minimal. Mild redness or bruising may occur temporarily. Plastic Surgeon application minimizes these risks.
Yes. A specialized "Brotox" protocol is applied for male anatomy and muscle structure. The aim is natural, light line preservation — never a frozen or artificial look.
Medical skin care is performed under Plastic Surgeon supervision using medical devices (HydraFacial, microneedling, PRP) and active ingredients. Unlike regular facials, it provides therapeutic solutions for acne, pigmentation and wrinkles.
Varies between 1-6 sessions depending on the skin issue. HydraFacial shows results from the first session; for acne or pigmentation, 4-6 sessions are recommended. Sessions are 2-4 weeks apart.
Yes. Special low-intensity protocols are applied for sensitive skin. After skin analysis, the appropriate product and device combination is determined by the Plastic Surgeon.
Oily/acne skin: HydraFacial + dermapen. Dry skin: skin booster + mesotherapy. Pigmented skin: chemical peeling + PRP. Anti-aging: PRP + exosome combinations are recommended.
Most treatments allow immediate return. Non-invasive procedures like HydraFacial are immediately suitable for social life. Slight redness may occur for 24-48 hours after microneedling.
Yes, but sun protection is essential. Laser and peeling treatments are preferred for autumn-winter. HydraFacial and exosome treatments can be safely performed in any season.
25 is ideal for preventive care. Acne treatment from age 16+, anti-aging protocols from age 30+. Personalized plans are created after skin analysis.
Exosomes are nano-sized bioactive vesicles released from stem cells. They contain growth factors, microRNA and proteins that support skin regeneration and hair follicle revitalization.
3-4 sessions for skin, 4-6 sessions for hair treatment. Sessions are 2-4 weeks apart. Initial effects are felt by session 2, lasting results become clear from month 3.
Exosomes contain 100-200x more growth factors than PRP. They show faster and more pronounced effects. However, combined use is also recommended depending on budget and skin condition.
Yes. The products used are produced under GMP standards, sterile and allergen-free. As they mimic the body's natural repair process, side effect risk is very low.
Highly effective for hair loss, thin/sparse hair, facial aging, fine wrinkles, acne scars, skin tone loss and under-eye hollowing.
Topical anesthetic cream is applied before the procedure. Performed via microneedling or injection; most patients report only mild tingling, no pain.
Single session effect lasts 6-9 months. Full protocol (3-4 sessions) provides 12-18 months of lasting effect. Maintained with 1-2 annual sessions.
— BOTOX —
— MEDICAL SKIN CARE —
— EXOSOME THERAPY —
Contact us for consultation
You can book an appointment to learn more about the treatment suitable for you.
⚕ Medical Disclaimer
The information on this page is for general informational purposes only and does not constitute medical advice. Indications, dosages, and outcomes may vary between individuals. Before any aesthetic treatment, please schedule a free skin analysis and medical consultation at our clinic.
🌟 Our Popular Treatments
Polynucleotide PN-HPT Process
- 🔬 Skin Age Analysis: Skin elasticity and aging level determined.
- 🧬 PN-HPT Prep: High Purity Technology salmon DNA-derived polynucleotides.
- 💉 Microinjection: Mesogun or manual. Face, neck, décolleté.
- ⏱️ Result: 3-4 sessions, 2 weeks apart. 8-12 month effect — DNA-level regeneration.
Why Polynucleotide at Veneta Aesthetics Clinic®?
- ✅ PN-HPT high purity technology
- ✅ Plinest, Newest — original Mastelli
- ✅ DNA-level regeneration
- ✅ Safe for sensitive areas
- ✅ Combinable with other fillers
🛡️ Polynucleotide Safety
CE approved salmon-derived PN-HPT. High purity (>99.5%). Pregnancy, allergy, active infection contraindicated. Side effects: mild redness 24h.